منابع مشابه
nNOS-containing perivascular nerves: stranger by the minute.
Nitric oxide (NO) is known to play a major role in regulation of cerebral vascular tone.1 Under normal conditions, both endothelial NO synthase (eNOS) and neuronal NOS (nNOS) influence the vasculature. Within neurons, nNOS in present in a variety of parenchymal neurons as well as in a dense network of perivascular fibers that innervate the adventitia of blood vessels from sources such as the sp...
متن کاملPerivascular nerves and vascular endothelium: recent advances.
Within the last few years, advances have been made regarding perivascular nerves and the endothelium of the vascular system, both potentially important in the understanding of the mechanisms of local control of blood flow. Endothelin-1 (ET-1) has been identified in rat cerebrovascular nerves, neuropeptide Y (NPY) has been demonstrated in umbilical endothelium, the arginine-vasopressin (VP) syst...
متن کاملNitric oxide from perivascular nerves modulates cerebral arterial pH reactivity.
In the isolated rat middle cerebral artery (MCA) we investigated the role of nitric oxide (NO)/cGMP in the vasodilatory response to extraluminal acidosis. Acidosis increased vessel diameter from 140 +/- 27 microm (pH 7.4) to 187 +/- 30 microm (pH 7.0, P < 0.01). NO synthase (NOS) inhibition by N(omega)-nitro-L-arginine (L-NNA, 10 microM) reduced baseline diameter (103 +/- 20 microm, P < 0.01) a...
متن کاملPerivascular nerves and the regulation of cerebrovascular tone.
Brain perfusion is tightly coupled to neuronal activity, is commonly used to monitor normal or pathological brain function, and is a direct reflection of the interactions that occur between neuronal signals and blood vessels. Cerebral blood vessels at the surface and within the brain are surrounded by nerve fibers that originate, respectively, from peripheral nerve ganglia and intrinsic brain n...
متن کاملRenal nerves and nNOS: roles in natriuresis of acute isovolumetric sodium loading in conscious rats.
It was hypothesized that renal sympathetic nerve activity (RSNA) and neuronal nitric oxide synthase (nNOS) are involved in the acute inhibition of renin secretion and the natriuresis following slow NaCl loading (NaLoad) and that RSNA participates in the regulation of arterial blood pressure (MABP). This was tested by NaLoad after chronic renal denervation with and without inhibition of nNOS by ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000026649.69203.0a